Science Museum Oklahoma invites visitors to explore the physical sciences, invention, and technology. The exhibit "Destination Space" looks at space exploration, while "Aviation" follows the history of flight, and a model train exhibit recreates a town from 1900 to 1950. The museum also houses the International Gymnastics Hall of Fame, honoring the sport of gymnastics.

The museum offers exhibits, demonstrations, summer camps, planetarium shows, dome-screen film screenings, overnight in-museum programs, and other recreational and educational events.