Ulysses S. Grant was born 27 April 1822 in picturesque Point Pleasant near the mouth of Big Indian Creek at the Ohio River. This restored one-story, three-room cottage, which was built in 1817, was next to the tannery where Grant's father worked. The small cottage is furnished with period items. At one time the birthplace made an extensive tour of the United States on a railroad flatcar and was also temporarily displayed on the Ohio State fairgrounds.

The site offers tours.