The American Museum of Fly Fishing maintains the world's largest collection of angling and angling-related items, numbering in the thousands. Its collections and exhibits thoroughly document the evolution of fly fishing as a sport, art form, craft, and industry in the U.S. and abroad, dating as far back as the 16th century. Rods, reels, flies, tackle, art, photographs, manuscripts, and books form the major portions of the Museum's collections.

The museum offers exhibits and occasional recreational and educational events.

The Texas Maritime Museum provides exhibits on the history and technology of offshore petroleum production and transportation; the history and development of Texas seaports, maritime communities, and maritime commerce along the Gulf; the exploration and settlement history of the Texas Gulf Coast, including by the Spanish and the French; and an overview of the Texas seafood and fishing industry.

The museum offers exhibits, tours for school groups, in-class outreach presentations, traveling trunk "treasure chests" for loan, and occasional recreational and educational events.

Located at the site where 59 delegates gathered on March 2, 1836 to declare Texas's independence from Mexico, the Star of the Republic Museum traces the history of the Texas Republic (1836–1846) and interprets the history, cultures, diversity, and values of early Texans. Through 10,000 square feet of exhibits and audiovisual presentations, the Museum presents the experiences of ordinary Texans and extraordinary events. The exhibits emphasize social and cultural history, as well as military and political events. Primary memoir accounts are used as much as possible to let the people of the Republic tell their story "in their own words." Exhibits are designed to interpret interesting and significant artifacts with photographs, graphics, contextual material, and text labels. The interpretation of the artifacts also includes the social context of the objects, illustrating the people and values from which they were produced. In addition, seasonal exhibitions, special events, and interpretive demonstrations illustrating early 19th-century life are regularly scheduled, while the Showers Brown Discovery Center incorporates hands-on educational activities to help visitors make a personal connection with the past.

The museum offers exhibits, tours, reference library access, and occasional recreational and educational events.

The Corpus Christi Museum of Science and History presents the story of a cultural crossroads of the New World. With a confluence of natural history, science, people, and environments, the South Texas area has served as a stage for the ongoing discovery of the Americas. The museum's exhibits explore natural history and South Texas history, and include full-size, functioning reconstructions of Christopher Columbus's three ships.

The museum offers exhibits, self-guided and guided tours for school groups, tours of the Columbus Ships, traveling trunks available for rent, and occasional recreational and educational events.

The Heritage Farmstead preserves a representative example of Blackland Prairie farm culture and history from about 1890 to 1920 on its four-acre farmstead site. The centerpiece 1891 Farrell-Wilson house represents the daily life of a prosperous farm family on the North Texas Blackland Prairie.

The farmstead offers exhibits; guided tours by costumed docents, which may be adapted for school groups; living history demonstrations; and recreational and educational events.

The Country Music Hall of Fame and Museum presents the history of country music through its permanent exhibit, "Sing Me Back Home," showcasing both the music and the artifacts behind and surrounding it—costumes, lyrics sheets, musical instruments. It also hosts traveling and changing exhibits and programs and performances.

The museum offers exhibits, tours and in-museum workshops for school groups, curriculum guides, and educational and recreational events.

The B. Carroll Reece Memorial Museum, part of the East Tennessee State University, houses the University's Art Department's permanent collection of works of art and a historical collection which serves to preserve the story of the settlement of Johnson City, Washington County, and the surrounding region.

The museum offers exhibits and occasional recreational and educational events, including art classes for students.

The Hershey Story takes visitors on a journey through the life of Milton S. Hershey: the man, his chocolate company, the town that bears his name, and his legacy. It explores the accomplishments of an American entrepreneur through interactive museum exhibits and laboratory classes.

The museum offers exhibits, in-museum interactive classes and scavenger-hunt tours for school groups, workshops for visitors, and educational and recreational events.

The West Point Museum maintains the oldest and largest diversified public collection of miltaria in the Western Hemisphere. Its collections include nearly all aspects of military history and encompass the history of West Point and the United States Military Academy, the evolution of warfare, and the development of the American Armed Forces.

The museum offers exhibits on the full arc of U.S. military history.

NOTE: The Museum is located on West Point U.S. Military Academy grounds and is not available for self-guided tour without prior orientation at the Visitors Center.

The Shaker Museum interprets Shaker life and culture and exhibits artifacts from Shaker history, including Shaker furniture, oval boxes, textiles, craft machinery, art, tools, and agricultural machinery. The Shaker Library holds archival materials including books and historic pictures.

The museum offers exhibits; the research library offers library access, by appointment only.

NOTE: The museum and library are currently closed while the institution relocates to a new site at historic Mount Lebanon.