The Tower Grove House is an 1849 Italianate residence. The original owner, Henry Shaw, created the Tower Grove Park and the initial stages of the Missouri Botanical Garden.

The house offers tours.

The 19th-century mill and its neighboring covered bridge offer a glimpse of now-rare Americana that once might have been expected around many turns in a Missouri road. The present mill, dating to the Civil War period, is a massive four-story stone and brick building where visitors can still observe corn being ground into meal by water power—just as it was done long ago. The succession of three mills that have stood on this site represent more than 200 years of milling history. The Burfordville Covered Bridge standing alongside stretches its 140-foot span across the Whitewater River, which powers the mill. Begun in 1858, it is the oldest of only four remaining covered bridges in Missouri.

The site offers exhibits, tours, demonstrations, and occasional recreational and educational events.

On a high sand terrace above the Des Moines River floodplain in northeast Missouri sets Iliniwek Village State Historic Site, the largest and best preserved remnant known of any Illinois Indian village. This site was occupied from ca. A.D. 1640-1683, when Europeans were just contacting Native Americans in this region. During excavations in the 1990s, the locations of numerous houses, storage pits and even a ditch and palisade fortification were discovered. The Illinois Indians were the first Native Americans that Louis Jolliet and Father Jacques Marquette encountered in present-day Missouri in 1673. At that time, the village contained 300 lodges and perhaps 8,000 people. Evidence of early European contact appears in archaeological finds through glass beads, metal objects, and Jesuit trade rings. The historic site interprets the history and daily life of the Illinois Indians and the Jolliet and Marquette expedition of 1673. A short walking trail crosses the site, and the location of an excavated Illinois Indian longhouse is marked to show its size.

The site offers exhibits, tours, and occasional recreational and educational events.

In a modest walk-up flat at 2658A Delmar Boulevard, Scott Joplin and his new bride Belle began their life in St. Louis. It was then called Morgan Street, a busy, densely populated, blue-collar district of African Americans and German immigrants. Located nearby were the honky-tonks and dives of the notorious Chestnut Valley. This black musical genius, buoyed by his success with the Maple Leaf Rag, was making his move toward the national arena. He would soon be known as the "King of Ragtime." Lit by gaslight, and appropriately furnished for 1902, the Joplin flat where many ragtime classics were composed awaits visitors. The building also has museum exhibits interpreting Joplin's life and work, and St. Louis during the ragtime era. The new Rosebud Cafe, a reconstructed structure that recreates a local turn-of-the-century bar and gaming club, is available to rent for gatherings.

The site offers exhibits, tours, and occasional recreational and educational events.

It was once called "the largest and best arranged dwelling house west of St. Louis." Today Oliver Anderson's mansion is best known for the three bloody days in 1861 when it was a fiercely contested prize in a Civil War battle between the Union army and the Missouri State Guard. Today, it is restored and furnished in the mid-19th-century fashion, but it still displays damage from the shot and shell that hammered it during the Battle of Lexington. The house changed hands three times, and soldiers met their death in the downstairs hallway. The battlefield is quiet now, and restored gardens and orchards dot the landscape. But the remnants of the trenches can still be seen, and the graves of unknown Union dead echo a time less peaceful. In addition to tours of the 1853 Anderson House, visitors may explore the 100 acres of the battlefield preserved at the historic site. A visitor center with exhibits and audiovisual programs explains the stirring events of Sept. 18–20, 1861, and why the "Battle of the Hemp Bales" lifted Southern spirits and further dampened Northern hopes of an easy victory in the struggle for Missouri.

The site offers exhibits, tours, a short film, occasional living history events, and occasional recreational and educational events.

In 1864, the Arcadia Valley was the scene of one of the largest and most hard-fought battles waged on the state's soil: the Battle of Pilot Knob. Confederate Maj. Gen. Sterling Price invaded Missouri from Arkansas, leading an army of 12,000 men. On Sept. 26–27, 1864, while en route to the St. Louis area, Price attacked the weakly defended Union post of Fort Davidson at Pilot Knob. This proved to be a mistake. Fort Davidson was defended by a garrison of 1,450 men led by Gen. Thomas Ewing Jr., the brother-in-law of Gen. William Tecumseh Sherman. The Confederates lost nearly 1,000 men in attacking the small earthen fort and its 11 cannons. Today, the site preserves Fort Davidson and the Pilot Knob battlefield where so many Confederate and Union soldiers lost their lives. A visitor center interprets the battle and Maj. Gen. Price's raid. It features exhibits, a research library, an audiovisual presentation, and a fiber optics diorama of the battle.

The site offers a short films, exhibits, research library access, tours, occasional living history events, and occasional recreational and educational events.

The Sappington Cemetery State Historic Site houses the grave of a prominent area doctor, Dr. John Sappington, along with two Missouri governors, Gov. Meredith Marmaduke and Clairborne Jackson, who was driven from the state when the Civil War began.

The site offers guided tours. The website offers visitor information.

The mansion at this site illustrates the grand lifestyle once enjoyed by one of southeast Missouri's wealthy families during the late 1800s. William and Amanda Hunter ran successful family enterprises in the thriving Mississippi River town of New Madrid, including a dry goods store and a floating store used to peddle goods to other towns. In 1859, they began planning their home, which took nearly a year to complete. William died before the house was complete, but Amanda and her seven children moved into the house in 1860—61. Upon Amanda's death in 1876, the Hunter's youngest daughter, Ella, and her husband William Dawson, a Missouri and United States legislator, moved into the house. Descendents of the Hunter family occupied the house continually until 1958. Today, visitors can take guided tours of the home, which is restored to the 1860—1880 period and features nine fireplaces. Most of the original furnishings purchased by Amanda Hunter remain, including a large collection of Mitchell and Rammelsberg furniture.

The site offers tours.

The Civil War may have ended in 1865, but vivid memories of the "Lost Cause" lived on for decades at the Confederate Soldiers Home of Missouri. Opened in 1891, the Confederate Home provided refuge to more than 1,600 veterans and their families for nearly 60 years. These veterans hailed from points throughout the South and served in every major battle of the Civil War. Foot soldiers, artillery and cavalrymen, marines, guerilla fighters, and even spies found a place of rest here in their old age. The very last of these former rebel soldiers, John T. Graves, died at the home in 1950 at the age of 108, thus bringing an end to an era in Missouri history. Today, visitors to the Confederate Memorial State Historic Site can venture to the locations of the former home buildings and stroll through the restored 106-year-old chapel and historic cemetery. Three other historic buildings can be viewed from outside. Interpretive exhibits tell the story of the state's Confederate Soldiers Home.

The site offers exhibits and tours.

Boone, youngest child of the famous Daniel Boone, carried his family's legacy deep into the Missouri Ozarks and the American West. Boone's last home, a simple but comfortable log house, invites exploration into the life of this second-generation frontiersman. Boone's three sons and two of his slaves built the house in 1837. It was the hub of a 720-acre Ozark farm. He, his wife, Olive, and other family members are buried near the house. Another cemetery, just a short distance from Boone's grave, contains the graves of at least 16 men, women, and children kept as slaves on the farm.

The site offers tours and occasional demonstrations and living history events.