In 1804, Lewis and Clark reported the presence of many saltwater springs in the area that now comprises Howard, Cooper, and Saline counties. The largest of these salt springs was the Boone's Lick. The area around this spring was ideal for settlement and for many years "Boone's Lick Country" was a primary destination for pioneers moving west. Nathan and Daniel Morgan Boone, sons of famous frontiersman Daniel Boone, formed a partnership with James and Jesse Morrison in 1805 to produce salt. Brine water was poured into iron kettles and heated to boiling on a stone furnace. As the water evaporated, salt crystallized in the bottom of the kettle. The salt was shipped by keelboat on the Missouri River to St. Louis. Salt, which was indispensable at the time for preserving meat and tanning hides, was produced at the site until approximately 1833. Today, the 52-acre site features picnic facilities and a short trail that winds its way to the spring site, where wood remnants of the salt works and an iron kettle are still visible. Outdoor exhibits interpret this unique saltwater environment and center of frontier industry. Artifacts from the salt manufacturing industry were excavated at the site, and some are on display at the Arrow Rock State Historic Site visitor center in Arrow Rock.

The site offers exhibits and occasional recreational and educational events.

The Pommer-Gentner house, built in 1840, is a sterling example of high-style German neoclassicism and is furnished to reflect the earlier settlement period of the 1830s and 1840s. Behind the house, visitors will tour a period garden and a small half-timbered barn containing an exhibit of 19th-century tools. The Strehly house, built in stages from 1842 to 1869, has a traditional German vernacular front. It once contained a full-service printing company that produced a German-language newspaper. About 1857, Carl Strehly built a winery next to the house that today displays one of a few remaining carved wine casks in the Midwest. Grapevines, planted by the Strehlys in the 1850s, can still be seen running the length of the backyard. Deutschheim's varied collections of German Americana are represented by galleries of changing artifacts and photographs.

The site offers tours, exhibits, occasional recreational and educational events.

Hot, smoky, noisy—these words describe how Hopewell Furnace looked from 1771 to 1883. Hopewell and other "iron plantations" laid the foundations for America's iron and steel industry. Today, the site stands as an example of America's development during the Industrial Revolution.

The site offers exhibits, tours, and occasional recreational and educational events (including living history events).

For over 400 years Ojibwe families of Grand Portage have tapped maples every spring on a ridge located just off Lake Superior. During the summer, Ojibwe fishermen harvest in the same areas their forefathers have. Before the United States and Canada existed, the trading of furs, ideas, and genes between the Ojibwe and French and English fur traders flourished. From 1778 until 1802, welcomed by the Grand Portage Ojibwe, the North West Company located their headquarters and western supply depot here for business and a summer rendezvous. Today, Grand Portage National Monument and Indian Reservation form a bridge between people, time and culture.

The site offers short films; tours; exhibits; educational programs; demonstrations; and educational and recreational events, including living history events.

The New Bedford Whaling National Historical Park presents the history of New Bedford, whaling capital of New England in the mid-19th century, and the trade itself. This is the only national park to focus on whaling and the whale oil industry. The park consists of a portion of New Bedford itself, the starting point for the fictional voyage chronicled in Herman Melville's Moby Dick, as well as the majority of American whaling expeditions. Voyages could last upwards of five years per voyage, but were crucial to providing whale oil to light the 1800s United States.

The park offers an introductory film; exhibits on area preservation, whaling, and commercial fishing; a guided tour; self-guided tours on whaling and on the Underground Railroad; and Junior Ranger activities. The park is partners with the following area institutions: the New Bedford Whaling Museum, Rotch-Jones-Duff House and Garden Museum, Seamen's Bethel, Waterfront Visitor Center and Schooner Ernestina. Partner institutions offer more than 60 educational programs.

The Edison National Historic Site consists of the home and laboratory of Thomas Edison, preserved as they were during the late 1800s.

The home offers tours, artifacts, and exhibits that showcase Edison's life and career.; it also offers videos for loan to educators. The website offers a biography of Edison, a history of the home, original phonograph recordings, visitor information, and a calendar of events.

The Inupiat Heritage Center presents the history and culture of the Inupiat people. Originally the only hunters of the bowhead whale, or Agviq, in the region, during the 19th century they came into contact with New England whalers. After this point, many Inupiat crewed on New Bedford vessels and/or traded with the commercial whalers.

The center offers exhibits, a traditional room, activities, tours, storytelling, lectures, dance performances, and Junior Ranger activities. The website offers a booklet of activities to be completed during school visits.