The Old Slave Mart, located on one of Charleston's few remaining cobblestone streets, is the only known extant building used as a slave auction gallery in South Carolina. Once part of a complex of buildings, the Slave Mart building is the only structure to remain. When it was first constructed in 1859, it has gone through numerous renovations and today serves as a museum, with a permanent exhibition divided into two main areas. In the orientation area, visitors receive an introduction to the domestic slave trade within the greater historical context of slavery in the United States as well an overview of the trans-Atlantic slave trade. In the main exhibit area visitors will also get a closer look at the daily process of slave sales at Ryan's Mart from the perspectives of a number of its historically documented buyers, traders, and enslaved African Americans. This section explains this antebellum slave market's role within Charleston's larger, but concentrated, slave-trading district.

The museum offers exhibits.

Drayton Hall, on which construction began in 1738, is the oldest surviving example Georgian Palladian architecture in the U.S. and one of the only pre-Revolutionary houses that remain in close-to-original condition today.

The house offers exhibits, tours, and educational and recreational events and programs.

Built almost 40 years prior to the American Revolution, the Hopsewee Plantation House, still a private residence, is a typical low-country rice plantation dwelling of the early 18th century, with four rooms opening into a wide center hall on each floor, a full brick cellar, and attic rooms. Constructed on a brick foundation covered by scored tabby, the house is built of black cypress. It is furnished in 18th- and 19th-century furniture.

The house offers tours.