The Junípero Serra Museum is one of the most familiar landmarks in San Diego. As a major symbol of the city, it stands atop the hill recognized as the site where California began. It was here in 1769 that a Spanish Franciscan missionary, Father Junípero Serra, with a group of soldiers led by Gaspar de Portolá, established Alta California's first mission and presidio (fort). On July 16, 1769, near the site where the museum now stands, Serra founded the Mission San Diego de Alcalá. Often confused for the Mission, the Serra Museum was built between 1928–1929 for the purpose of housing and showcasing the collection of the San Diego Historical Society, which was founded in 1928. The structure was designed by architect, William Templeton Johnson, using Spanish Revival architecture, to resemble the early missions that once dominated the landscape of Southern California.

The museum offers exhibits, tours, and educational programs.

Jefferson Landing State Historic Site is significant as a rare surviving Missouri River landing. The Lohman Building, built in 1839, is a sturdy stone structure that served as a tavern and hotel, and in its heyday also housed one of the city's largest warehouse and mercantile businesses. Today, the main floor contains a visitor center with exhibits on transportation. Across the street from the Lohman Building is the Union Hotel, built in 1855. Today, the hotel houses the Elizabeth Rozier Gallery with its program of rotating exhibits emphasizing Missouri art and culture. A block away, the Missouri State Capitol is more than just the seat of government. Inside the Capitol, the Missouri State Museum houses an impressive collection of exhibits that portray Missouri's history, legends, and cultural achievements. A free guided tour is recommended to fully experience this monument to Missouri, but visitors can explore the four floors of the Capitol by themselves.

The site offers exhibits, tours, and a short film.

The Society operates a museum which presents displays related to local history.

The museum offers exhibits and tours.

The National Afro-American Museum and Cultural Center aims to educate the public about African-American history and culture from African origins to the present through a variety of programs, including museum exhibits, research and publications, visiting scholars, oral and visual history, and adult and children's educational activities.

The museum and center offer exhibits and tours.

The Museum provides visitors with a journey through the history of flight. Visitors may stand beneath a model of the Montgolfier brothers' hot air balloon of 1783—the first manned vehicle in recorded history to lift man above the Earth. They can view specimens of aircraft from World War I, or marvel at the antics of the barnstormers of the 1920s. Mint condition aircraft help visitors appreciate the increasingly complex technology represented in the classic military aircraft of World War II, Korea, and Vietnam, and exhibits on space flight project aeronautics into the future.

The museum offers exhibits, tours, research library access, educational programs, and occasional recreational and educational events.

The Herreshoff Marine Museum / America's Cup Hall of Fame celebrates the unique accomplishments of the Herreshoff family and the related drama of the America's Cup races. From 1863 to 1945, the Herreshoff Manufacturing Company, on the site of the present day Museum, produced the world's finest yachts. The genius of naval architect Captain Nathanael Greene Herreshoff along with the business acumen of his blind older brother John Brown Herreshoff truly built the "better mouse trap" for which the world beat a path to Bristol. Today, visitors from around the world see the nation's finest collection of yachts, all Herreshoff and many more than 100 years old. They can view the design models recording Captain Nat's design genius and see the products of his innovations. The companion America's Cup Hall of Fame is the international center for appreciation of the Cup.

The museum offers exhibits, research library access, lectures, classes, and occasional recreational and educational programs; the hall offers exhibits.

The Museum and the Village, with its buildings and their contents, reflect life in Jefferson County from the mid-19th century to more recent years. Among the furnished buildings one finds homes of the 19th century, a one-room school, a log church and log jail, operating blacksmith and print shops, merchandise in the general store, and a variety of medical equipment from a foot-treadle dentist's drill to a Civil War amputation kit in the Medical Building. The Museum currently houses exhibits of the history of telephones and weaving and of military personnel and their lives from the Civil War to the current armed forces, as well as collections donated by Jefferson County residents.

The museum and village offer exhibits and occasional educational and recreational events.

Visitors to two of Leadville's earliest houses can catch a glimpse of western life in a booming silver-mining camp. James V. Dexter's surprisingly plush 1879 log cabin was the Leadville residence of this mining investor and businessman. August R. Meyer's 1878 Greek Revival clapboard house (now called Healy House) was built for his bride, Emma. The home features lavish Victorian furnishings collected in Leadville, including objects belonging to silver tycoon Horace and Augusta Tabor, along with other Leadville pioneers. For many years it was a boarding house and by 1900 twenty-one people called this home. The boarders included Dan Healy, and his cousin, Nellie, who taught school, and several of the men employed by the railroads.

The sites offer tours and educational programs.

In 1639, a group of Puritans led by their minister, Reverend Henry Whitfield, built the stone house in which this museum is housed. As well as serving as a home for the Whifield's, it was also a fort for the community. Its massive stone walls and chimneys, steeply-pitched roof, and casement windows reflect the style of post-medieval domestic architecture found in England—rare in 17th-century America and unique today. It is Connecticut's oldest house and New England's oldest stone house.

The museum offers exhibits, research library access, tours, and educational and recreational programs.

The Friendship Fire Company was established in 1774, and was the first volunteer fire company in Alexandria. The current firehouse was built in 1855, remodeled in 1871, and renovated in 1992. The Engine Room on the first floor houses hand-drawn fire engines, leather water buckets, axes, sections of early rubber hose, and other historic fire-fighting equipment. An exhibition discusses the development of firefighting technology and other fire companies that have served the citizens of Alexandria. The second floor Meeting Room is furnished the way it was during the late 19th century, the real heyday of Friendship as a community organization. On view here are various ceremonial objects such as parade uniforms, capes, banners, and other regalia. George Washington's association with the Friendship Fire Company, honored by members for over 200 years, is symbolized by several images of him throughout the museum.

The museum offers exhibits, tours, educational programs, and occasional recreational and educational events.