Located along the original Route 66 corridor, the nearly 419-acre park is a boon to park visitors who want to enjoy nature and see interesting historical displays showcasing Route 66. Bridgehead Inn, a 1935 roadhouse, serves as Route 66 State Park's visitor center. It houses Route 66 memorabilia and interprets the environmental success story of the former resort community of Times Beach, which once thrived on the location of the park.

The park offers exhibits.

This modern museum has three major exhibit areas. First is the National Road, early America's busiest land artery to the West. The National Road stretched from Cumberland, MD, to Vandalia, IL. Begun in 1806, the "Main Street of America" was the only significant land link between east coast and western frontier in the early 19th century. A 136-foot diorama of the National Road plus many objects illustrates this theme. Second is Zane Grey, the "Father of the Adult Western." The Zanesville author wrote more than 80 books. His study is recreated plus many manuscripts and other memorabilia are displayed. Finally, a central portion of the museum is devoted to Ohio art pottery.

The museum offers exhibits, tours, and educational programs.

The Piqua Historical Area State Memorial celebrates 2,000 years of Ohio's rich history from prehistoric Indians to Ohio's canal era. The focal point of the peaceful 200-acre park is John Johnston—farmer, public official, and United States Indian Agent for western Ohio from 1812 to 1829. Today, visitors enjoy the home and farm of this most extraordinary man much as it appeared in 1829. Preserved and furnished structures include Johnston's two-story mixed Dutch Colonial/Georgian style farmhouse, a unique two-story spring house, and a cider house. Costumed interpreters and craft demonstrators provide farm tours and display activities in the summer kitchen and fruit kiln areas. A mammoth double-penned log barn, constructed in 1808, is reputed to be the oldest and largest of its type in Ohio, and is still in use on the grounds. Nearby a ring-shaped mound earthwork discovered and preserved by Johnston was constructed by people of the Adena culture over 2,000 years ago. Not far from Johnston's farm is a modern museum, which was constructed to resemble the blockhouse style of Fort Piqua, General Anthony Wayne's 18th-century supply post. In 2001 the museum was renovated with updated exhibits that trace the story of the Eastern Woodland Indians of Ohio and the newly acquired Fort Pickawillany site. Artifacts from Ohio's canal era are also on exhibit. The patio portion of the museum building allows visitors the opportunity to view a restored mile-long section of the Miami and Erie Canal, which extended the length of Ohio from Toledo to Cincinnati. An array of outdoor interpretive panels explore Johnston's later role as a state canal commissioner and provide an introduction to how canals helped in the development and expansion of frontier Ohio. Afterwards, guests may enjoy a ride aboard the General Harrison of Piqua, a replica 70-foot-long mixed cargo canal boat often used for transportation of passengers and cargo in the 19th century. Costumed guides direct the mule-drawn boat to provide an authentic and memorable experience for all.

The site offers exhibits; tours; demonstrations; boat rides; and recreational and educational events, including living history events.

Marietta, Ohio is proud of its riverboat heritage and at the Ohio River Museum visitors can discover the golden age of the steamboat, and learn more about the ecology of the Ohio River system. The Ohio River Museum consists of three exhibit buildings, the first of which houses displays depicting the origins and natural history of the Ohio River. The history of the steamboat on the Ohio River system is featured in the second building, along with a video presentation on river steamboats. The last building features displays about boat building, mussels in the Ohio River system, and tool sand equipment from the steamboat era. Outside the museum, on the Muskingum River, visitors can take an escorted tour of the W.P. Snyder Jr.—the last intact steam-powered "pool-type" stern-wheeled towboat in the United States. Other exhibits on the museum grounds include the pilothouse from the steamboat Tell City as well as a full-scale reproduction of a flatboat from Ohio's early settlement period. Also on site are a series of poles showing the heights of some of the worst floods to hit the area in its recorded history: the 1884 flood at 54.5 feet, the 1898 flood at 49.6 feet, the 1907 flood at 52.1 feet, the flood of 1913 at 60.3 feet, and the 1937 flood at 55 feet.

The museum offers exhibits, a short film, tours, and educational programs.

The Union Pacific Railroad Museum houses one of the oldest corporate collections in the nation. It includes artifacts, photographs, and documents that trace the development of the railroad and the American West. The Union Pacific Collection dates to the mid-1800s, featuring original editions of reports from survey teams that searched for the best land route to join the nation, east to west. Surveying equipment, early rail equipment, and artifacts from the construction of the nation's first transcontinental railroad tell the story of one of the world's construction marvels.

The site offers exhibits.

In 1864, Ben Holladay was awarded a contract to deliver mail from Salt Lake City to Walla Walla, WA. Rock Creek became a "home station," where stage drivers and attendants lived while they were off-duty and where passengers could buy a meal or a night's lodging. The original station consisted of a lava-rock building that served as a hotel and barn. In 1865 a store was built at the site. A small community grew up around the business, which also became a social center.

The site offers tours.

Completed by the Baltimore & Ohio Railroad in 1831, this National Historic Landmark is the oldest railroad station in America. The site showcases the people who built and operated America's first railroad, tells stories of soldiers and citizens caught in the turmoil of the Civil War, and highlights the clash of technology that transformed America's transportation systems from roads to rails.

The site offers exhibits, tours, and recreational and educational events (including living history events).

On April 3, 1860, a lone rider left on horseback from the gates of one of the nation's now-historic landmarks, the Pikes Peak Stables in St. Joseph, MO. Carrying saddlebags filled with the nation's hopes and dreams, the riders traveled 2,000 miles west to Sacramento, CA. These brave young souls raced against nature's cruel elements and rugged terrain in an attempt to unite a country separated by distance. Today, the stables continue to stand as a tribute to the legend and legacy of the Pony Express and its enduring era. The Museum invites visitors to come and experience the many exciting, educational, state-of-the-art exhibits conveying the need, creation, operation, and termination of the Pony Express.

The museum offers exhibits, tours, and occasional recreational and educational events.