The Harriet Beecher Stowe House is operated as an historical and cultural site, focusing on Harriet Beecher Stowe, author of Uncle Tom's Cabin. The site also includes a look into the family, friends, and colleagues of the Beecher-Stowe family; Lane Seminary; and the abolitionist, women's rights, and Underground Railroad movements in which these historical figures participated in the 1830s to 1860s, as well as African-American history related to these movements. The house was home to Harriet Beecher Stowe prior to her marriage and to her father, Rev. Lyman Beecher, and his large family, a prolific group of religious leaders, educators, writers, and antislavery and women's rights advocates. The Beecher family includes Harriet's sister, Catherine Beecher, an early female educator and writer who helped found numerous high schools and colleges for women; brother Rev. Henry Ward Beecher, a leader of the women's suffrage movement and considered by some to be the most eloquent minister of his time; General James Beecher, a Civil War general who commanded the first African-American troops in the Union Army recruited from the South; and sister Isabella Beecher Hooker, a women's rights advocate. The Beechers lived in Cincinnati for nearly 20 years, from 1832 to the early 1850s, before returning East.

The house offers exhibits, tours, and occasional recreational and educational programs and events.

The Rankin House was an important stop on the Underground Railroad in southern Ohio through which many slaves escaped from the South to freedom. John Rankin was a Presbyterian minister and educator who devoted much of his life to the antislavery movement. In 1826 he published his antislavery book, Letters on American Slavery. In 1834 he founded the Ohio Anti-Slavery Society in Zanesville. From 1825 to 1865, Rankin and his wife Jean, with their Brown County neighbors, sheltered more than 2,000 slaves escaping to freedom, with as many as 12 escapees being hidden in the Rankin home at one time. The house, a National Historic Landmark, is included in the National Underground Railroad to Freedom Network. Outside is a reconstruction of the stairway used by slaves to climb from the Ohio River to the Rankin House.

The house offers tours and educational programs.

Boone, youngest child of the famous Daniel Boone, carried his family's legacy deep into the Missouri Ozarks and the American West. Boone's last home, a simple but comfortable log house, invites exploration into the life of this second-generation frontiersman. Boone's three sons and two of his slaves built the house in 1837. It was the hub of a 720-acre Ozark farm. He, his wife, Olive, and other family members are buried near the house. Another cemetery, just a short distance from Boone's grave, contains the graves of at least 16 men, women, and children kept as slaves on the farm.

The site offers tours and occasional demonstrations and living history events.