Misión la Purísima Concepción de María Santísima (Mission of the Immaculate Conception of Most Holy Mary) was founded by Father Presidente Fermin de Lasuén on December 8, 1787. It was the 11th of 21 Franciscan Missions established in Alta California. A major earthquake on December 21, 1812, destroyed many of the mission buildings. Father Mariano Payeras received permission to relocate the mission community four miles to the northeast in La Cañada de los Berros, next to El Camino Real. La Purísima Mission was officially established in its new location on April 23, 1813. Materials salvaged from the buildings destroyed by the earthquake were used to construct the new buildings, which were completed within 10 years. The end of the California missions came in 1834, when the Mexican government, which had gained independence from Spain, transferred control of the missions from the Catholic Church to civil authorities. Today, La Purísima Mission State Historic Park is considered the most completely restored mission in California, with 10 of the original buildings fully restored and furnished, including the church, shops, quarters, and blacksmith shop. The mission gardens and livestock represent what would have been found at the mission during the 1820s. Special living history events are scheduled throughout the year. A visitor center features information, displays, and artifacts; and a self-guided tour gives visitors the opportunity to step back in time for a glimpse of a brief, turbulent period in California's history.

The site offers exhibits, tours, living history events, educational programs, and occasional other educational and recreational events.

The Mission San Luis recreates life at the time of Spanish settlement. The site depicts the ways of life of 17th-century Spanish settlers and the Apalachee people. Sights include the visitor's center, Apalachee council house, the Spanish Deputy Governor's home, and a Franciscan church and friary. Costumed living history interpreters show how the people interacted with each other, their material cultures, and the land.

The mission offers an introductory film, audio tours, exhibits, demonstrations, costumed living history interpreters, one- through three-hour interactive curriculum-based school tours, four curriculum-based school outreach programs, day camps, and workshops for adults. The film is captioned, audio tours are t-coil compatible, and arrangements can be made for a descriptive orientation for visually impaired visitors. Publications are available in Braille, and one exhibit was designed with the assistance of the Florida Division of Blind Services. Wheelchairs are available on request. The website offers pre- and post-visit lessons, vocabulary, and a teacher's guide