Fort Ancient features 18,000 feet of earthen walls built 2,000 years ago by American Indians who used the shoulder blades of deer, split elk antler, clam shell hoes, and digging sticks to dig the dirt. They then carried the soil in baskets holding 35 to 40 pounds. Portions of these walls were used in conjunction with the sun and moon to provide a calendar system for these peoples. The Museum at Fort Ancient contains 9,000 square feet of exhibits, including many interactive units, focusing on 15,000 years of American Indian history in the Ohio Valley.

The site offers exhibits, tours, educational programs, and occasional recreational and educational programs.

Atop a plateau overlooking the Brush Creek Valley, Serpent Mound is the largest and finest serpent effigy in the United States. Nearly a quarter of a mile long, Serpent Mound apparently represents an uncoiling serpent. In the late 19th century, Harvard University archaeologist Frederic Ward Putnam excavated Serpent Mound and attributed the creation of the effigy to the builders of the two nearby burial mounds, which he also excavated. This, this culture is referred to as the Adena (800 BC–AD 100). A third burial mound at the park and a village site near the effigy's tail belong to the Fort Ancient culture (AD 1000–1550). A more recent excavation of Serpent Mound revealed wood charcoal that could be radiocarbon dated. Test results show that the charcoal dates to the Fort Ancient culture. This new evidence of the serpent's creators links the effigy to the elliptical mound and the village rather than the conical burial mounds. The head of the serpent is aligned to the summer solstice sunset and the coils also may point to the winter solstice sunrise and the equinox sunrise. Today, visitors may walk along a footpath surrounding the serpent. The museum contains exhibits on the effigy mound and the geology of the surrounding area.

The site offers exhibits and tours.

Named in honor of Henry Laurens, then president of the Continental Congress, Fort Laurens was built in 1778 in an ill-fated campaign to attack the British at Detroit. Supplying this wilderness outpost was its downfall, as its starving garrison survived on boiled moccasins and withstood a month-long siege by British-led Indians. The fort was abandoned in 1779. Today, only the outline of the fort remains, but a small museum commemorates the frontier soldier, presents a video giving the fort's history, and displays archaeological artifacts from the fort's excavation. The large park surrounding the museum is the location for periodic military reenactments. The remains of the soldiers who died defending the fort are buried in a crypt in the museum wall and at the Tomb of the Unknown Patriot of the American Revolution.

A second website covering the site, the Friends of Fort Laurens website, can be found here.

The site offers a short film; exhibits; and occasional recreational and educational events, including living history events.

The Felix Vallé State Historic Site is designed to offer visitors a rare glimpse of Missouri's French colonial past. From the historic site's website, "The site features the Felix Vallé House built in 1818 as an American-Federal style residence and mercantile store. Restored and furnished to reflect the 1830s, the home today interprets the American influence on the French community following the Louisiana Purchase." In addition to the Felix Vallé House, the historic site also features the Benjamin Shaw house and the 1792 Bauvais-Amoureux House.

The State Historic Site offers guided tours and interpretive activities, and serves as the headquarters for the Historic Preservation Field School. The website offers visitor information as well as a brief history of the site.

St. Joseph Lead Co. dominated ore production and became the heart of the easter Ozarks' Old Lead Belt, continuing operations in this district until 1972. In 1975, the company donated the 25 buildings of their largest mine-mill complex and the surrounding land to the Missouri Department of Natural Resources. These properties became Missouri Mines State Historic Site and St. Joe State Park. The 19,000 square-foot mine-mill powerhouse has been developed into a large museum that interprets Missouri's mining history and displays old mining machinery and an outstanding mineral collection.

The site offers a short film, exhibits, tours, and occasional recreational and educational events.