The National Mississippi River Museum & Aquarium presents the history of the Mississippi River. Topics covered include famous men who made contributions to national river culture, riverboats, Other points of interest include a Native American wikiup; a restored fur trader's cabin; and the 1934 steamer W.M. Black , which was used as a dredge boat in WWII.

The museum offers traditional and interactive exhibits, a theater, a towboat pilothouse simulator, period rooms, tours of the W.M. Black, living history demonstrations, tours for field trips, educational programming, outreach programming, and overnight opportunities. The website offers lesson plans, curriculum

The Oregon-California Trails Association seeks to preserve and heighten awareness of the history of emigrant trails and the people who made use of them.

The association website offers a virtual trail tour, historical information on a variety of topics pertinent to life on the trails, emigrant profiles, and information on locations and grave sites along the trail.

Bryant Cottage was built in 1856 by Francis E. Bryant (1818–1889), a friend and political ally of Senator Stephen A. Douglas. According to Bryant family tradition, on the evening of July 29, 1858, Douglas and Abraham Lincoln conferred in the parlor of this house to plan the famous Lincoln-Douglas Debates. The one-story, four-room wood frame cottage has been restored and is interpreted as an example of middle-class life in mid-19th-century Illinois. The furniture on display is of the Renaissance Revival style, appropriate for a small-town family of the mid-19th century.

The site offers tours and occasional recreational and educational events.

In partnership with the Princeville Civic Association, the Society operates the Princeville Heritage Center, a 15,000-square-foot facility which features living interpreted displays of antique agriculture equipment, steam-powered tractors and threshers, area artifacts, automobiles, sporting goods, and quilting. In addition to the original facility, the Society has also erected a second 8,400-square-foot building for agricultural equipment display. It displays old photographs, household items, area artifacts, steam-powered tractors, threshing equipment, grain binders, quilting, automobiles, gas engines, and numerous other items.

The center offers exhibits.

The American Jazz Museum showcases the sights and sounds of a uniquely American art form through interactive exhibits and films; the Changing Gallery; the Blue Room jazz club; and the Gem Theater, a 500-seat performing arts center. The collections include artifacts related to jazz greats Louis Armstrong, Duke Ellington, Ella Fitzgerald, and Charlie Parker, as well as over 100 recordings. Other highlights include the Charlie Parker Memorial and a major collection of more than 5,000 jazz films.

The museum offers exhibits, films, performances, educational programming, and 16 interactive listening and mixing stations.

The National Museum of Roller Skating contains the largest collection of historical roller skates, dating to 1819, in the world. It also contains patents, medals, trophies, photographs, artwork, films and videotapes, costumes, library and archival materials, and roller skating memorabilia. The museum holds approximately 1,500 volumes of roller skating books and periodicals, including over 125 titles (American and foreign) in its periodical collection. The archives also includes over 8,000 photographs; personal papers of individuals prominent in roller skating from 1800 to the present; programs and archival material for local, regional, national, and international roller skating competitions; and miscellaneous articles and images related to roller skating.

The museum offers exhibits and films.

The Fort Wayne Railroad Historical Society restores and operates steam locomotives relevant to Midwestern history. The society also operates TrainTown, a transportation museum.

The museum offers self-guided tours and 20-minute caboose rides. The website offers historic photographs.

The McLean County Historical Society preserves local history, and shares it with the public via a series of museums located in Washburn, North Dakota. These museums consist of two main museum buildings, the Joe Taylor Cabin (1869), the Sioux Ferryboat (in use 1952–1962), and an old school house (1882). The main museum buildings contain fossils, information on Lewis & Clark, farming tools, military memorabilia, models of historic structures, Native American artifacts, coal industry history, musical instruments, train station artifacts, memorabilia from local organizations, and a variety of period room dioramas.

The museums offer exhibits.

This 1740 building is historically significant as the oldest courthouse in Illinois and the only one remaining from the state’s territorial period (1787–1818). It is architecturally significant as an example of the French Colonial vertical log poteaux-sur-solle ("post-on-sill") construction technique. Inside are three exhibit rooms and another furnished to represent the courtroom in the 1790s. Exhibits in the Courthouse depict issues that came before the court around 1800 and a history of the structure as it was moved in the early 20th century to St. Louis and Chicago before its eventual return to Cahokia.

The site offers exhibits, tours, and occasional recreational and educational events.

Fort Buford State Historic Site preserves remnants of a vital frontier plains military post. Fort Buford was built in 1866 near the confluence of the Missouri and Yellowstone Rivers, and became a major supply depot for military field operations. Original features still existing on the site include a stone powder magazine, the post cemetery site, and a large officers' quarters building which now houses a museum. Fort Buford, located near present-day Williston, was one of a number of military posts established to protect overland and river routes used by immigrants settling the West. While it served an essential role as the sentinel on the northern plains for 19 years, it is probably best remembered as the place where the famous Hunkpapa Sioux leader, Sitting Bull, surrendered in 1881.

The site offers a short film, tours, exhibits, and occasional recreational and educational events.