Atop a plateau overlooking the Brush Creek Valley, Serpent Mound is the largest and finest serpent effigy in the United States. Nearly a quarter of a mile long, Serpent Mound apparently represents an uncoiling serpent. In the late 19th century, Harvard University archaeologist Frederic Ward Putnam excavated Serpent Mound and attributed the creation of the effigy to the builders of the two nearby burial mounds, which he also excavated. This, this culture is referred to as the Adena (800 BC–AD 100). A third burial mound at the park and a village site near the effigy's tail belong to the Fort Ancient culture (AD 1000–1550). A more recent excavation of Serpent Mound revealed wood charcoal that could be radiocarbon dated. Test results show that the charcoal dates to the Fort Ancient culture. This new evidence of the serpent's creators links the effigy to the elliptical mound and the village rather than the conical burial mounds. The head of the serpent is aligned to the summer solstice sunset and the coils also may point to the winter solstice sunrise and the equinox sunrise. Today, visitors may walk along a footpath surrounding the serpent. The museum contains exhibits on the effigy mound and the geology of the surrounding area.

The site offers exhibits and tours.

Pinson Mounds, one of two state archaeological parks, is a special park, set aside to protect the prehistoric remains found there. The Pinson Mounds grouping consists of at least 15 earthen mounds, a geometric enclosure, habitation areas, and related earthworks in an area that incorporates almost 1,200 acres.

The site offers exhibits, tours, educational programs, and occasional educational and recreational events.

The Marksville State Historic Site is located on a bluff overlooking the Old River, and was the site of an Indian ceremonial ground. The site is believed by archaeologists to have national significance, and is thought to have been created by a subset of the Hopewell Indians of Ohio. The site is a National Historic Landmark.

The historic site offers guided tours, as well as exhibits and presentations in the park's visitor center. The website offers a history of the site, visitor information, and a short video commemorating the historical significance of the site.

The 128-acre Grand Village of Natchez Indians was the key ceremonial site of the Natchez people between 1682 and 1729. At the end of this period, the Natchez attacked the French who had settled in their homeland, southwest Mississippi. The French secured such a decisive victory that the Natchez were permanently dispersed in 1729. The Natchez people had called southwest Mississippi their home from as early as approximately 700. The Natchez were farmers, hunters, and gatherers; and their society was organized into two moieties, with membership determined by matrilineal inheritance. The site includes a museum, a reconstructed Natchez dwelling, and three earthen mounds—the Great Sun's Mound, the Temple Mound, and the Abandoned Mound. The Temple Mound once supported a temple which housed the remains of Natchez leaders.

The village site offers exhibits, a reconstructed period dwelling, a nature trail, a children's hands-on area, group tours, and student educational programs. Reservations are required for group tours and educational programs.

The Vincennes State Historic Sites commemorate Indiana's early state history—with the city itself founded in 1732. Structures include the 1805 Indiana Territory capital building; a historic print shop; the birthplace of the author Maurice Thompson; an 1838 bank; Fort Knox II, hospital to the wounded of the Battle of Tippecanoe; the 1801 Jefferson Academy; and a prehistoric burial mound. Maurice Thompson (1844-1901) authored 1900's bestselling romance novel, Alice of Old Vincennes. Topics covered include slavery, military life, domestic life, historical sciences, the fur trade.

The sites offer period rooms, educational outreach programs, group tours, educational presentations, interpretive signage, educational programs, lesson plans, and summer camps.

The 1,294-acre Kolomoki Mounds Historic Park contains a great temple mound, four ceremonial mounds, and two burial mounds built by the Swift Creek and Weeden Island Native Americans between the years 250 and 950.

The site offers exhibits, a film, and seven picnic areas. Picnic areas can be reserved.

The Wickliffe Mounds State Historic Site preserves the site of a Mississippian village and burial mounds. The Mississippians inhabited the village between 1100 and 1350. Exhibit topics include Mississippian artifacts, architecture, and burial practices. The village no longer exists, but the mounds are accessible. The Mississippians are also referred to as the Mound Builders.

The site offers exhibits, hands-on activities, museum tours, walking trails, educational programs, and a picnic site. The website offers pre-visit activities and guide sheets.

The Hopewellian mounds at Toolesboro are among the best-preserved and accessible remnants of an ancient culture flourishing from around 200 B.C. to 300 A.D. The five-acre site includes several large surviving mounds, an education center, and a prairie demonstration plot.

The site offers exhibits.

For more than a thousand years, Indians farmed on lands later known as North Carolina. Around A.D. 1200, a new cultural tradition arrived in the Pee Dee River Valley. Termed "Pee Dee" by archaeologists, it was part of a widespread tradition known as "South Appalachian Mississippian." These Native Americans established a political and ceremonial center at the Town Creek and Little Rivers. Here, visitors can now see a reconstructed ceremonial center, featuring a temple mound and major temple, minor temple, and burial hut.

The site offers a short film, exhibits, tours, and occasional recreational and educational events.