Salinas Pueblo Missions National Monument consists of 1,100 acres containing the ruins of four mission churches, located at Quarai, Abó, and Gran Quivira, in addition to the partially excavated pueblo of Las Humanas, otherwise known as Gran Quivira. Originally inhabited by the American Indian trade communities of Tiwa- and Tompiro-speaking Puebloans, in the early 17th century Spanish Franciscans visited the area and found it ripe for their missionary efforts. As of 1677 the entire Salinas District was depopulated of both Indian and Spaniard alike.

The monument offers museums, three historic sites, and an interpretive trail.

The Moravian church founded Schoenbrunn ("beautiful spring") in 1772 as a mission to the Delaware Indians. The settlement grew to include sixty dwellings and more than 300 inhabitants who drew up Ohio's first civil code and built its first Christian church and schoolhouse. Problems associated with the American Revolution prompted Schoenbrunn's closing in 1777. Schoenbrunn's story features a rare meeting of Indian and European cultures and a fascinating perspective on the American Revolution. Today the reconstructed village includes 17 log buildings, gardens, the original mission cemetery, and a museum and visitor center.

The village offers a short film, exhibits, and tours.

On a high sand terrace above the Des Moines River floodplain in northeast Missouri sets Iliniwek Village State Historic Site, the largest and best preserved remnant known of any Illinois Indian village. This site was occupied from ca. A.D. 1640-1683, when Europeans were just contacting Native Americans in this region. During excavations in the 1990s, the locations of numerous houses, storage pits and even a ditch and palisade fortification were discovered. The Illinois Indians were the first Native Americans that Louis Jolliet and Father Jacques Marquette encountered in present-day Missouri in 1673. At that time, the village contained 300 lodges and perhaps 8,000 people. Evidence of early European contact appears in archaeological finds through glass beads, metal objects, and Jesuit trade rings. The historic site interprets the history and daily life of the Illinois Indians and the Jolliet and Marquette expedition of 1673. A short walking trail crosses the site, and the location of an excavated Illinois Indian longhouse is marked to show its size.

The site offers exhibits, tours, and occasional recreational and educational events.

Iron Mission State Park Museum tells the story of development in Iron County when in the 1850s, Brigham Young sent Mormon missionaries here to mine and process iron. Museum displays include horse-drawn vehicles used from 1850 to 1920 and a collection of pioneer artifacts. An iron industry exhibit features the only known remaining artifact from the original foundry—the town bell. In addition to the permanent collections, changing special exhibits highlight artists from the local region, as well as rarely seen artifacts from the museum's collections. Other items of interest include several historic cabins, a large collection of horse-drawn farm equipment, and a replicated pioneer household. In addition, Iron Mission now manages the historic ruins of Old Iron Town, an iron foundry west of Cedar City that operated in the 1860s—1870s.

The site offers exhibits, tours, and occasional recreational and educational events.