This National Historic Landmark was the residence of two of Louisiana's foremost political figures, Edward Douglas White, who was governor from 1835 to 1839, and his son, Edward Douglass White, who was appointed to the U.S. Supreme Court in 1894 and served as chief justice from 1910 to 1921.

Today, an exhibit tells the story of the Bayou Lafourche area, with sections on the Chitimacha Indians, Acadian settlers, sugarcane plantations, slavery, and the White family.

The Presbytere, originally called the Casa Curial (Ecclesiastical House), derives its name from the fact that it was built on the site of the residence, or presbytere, of the Capuchin monks. It was designed in 1791 to match the Cabildo, or Town Hall, on the other side of St. Louis Cathedral. The building initially was used for commercial purposes until 1834 when it became a courthouse.

Today, the Presbytere offers exhibits on New Orleans history and culture.

Built in 1839, the Arsenal was designed by noted architect James Dakin and is associated with an infamous battle that happened after the Civil War. During the period of Reconstruction several clashes occurred throughout the state between integrated and white supremacist groups. In 1874, the Battle of Liberty Place, wherein the Metropolitan Police of New Orleans were pitted against the Crescent City White League, occurred. The White League prevailed, forcing the Metropolitan Police into the Customhouse and the Cabildo. From the adjacent Arsenal, the Police fought back by shooting cannonballs toward Chartres Street.

Today, the Arsenal offers exhibits and occasional recreational and educational events.

The Santa Fe Trail Center interprets the historic transportation route known as the Santa Fe Trail. This regional museum and library preserves artifacts and manuscripts related to the blending of the major cultures along the Trail and enhances understanding of the continued development of the Trail. The center presents interrelated interpretive exhibits, learning programs, and resource materials to engage the public in learning about its past.

The center offers exhibits, school tours, and research library access.

The collects and preserves artifacts that tell the story of the Frontier Army from 1804 to 1916, and Fort Leavenworth from 1827 to the present through the use of its collection of historical artifacts.

The museum offers exhibits.

The Harriet Beecher Stowe Center preserves and interprets Stowe's Hartford home and the Center's historic collections, promotes vibrant discussion of her life and work, and inspires commitment to social justice and positive change. A visit to the Center includes the Harriet Beecher Stowe House, a Victorian Gothic Revival home (1871) which includes Victorian-style gardens; the Katharine Seymour Day House (1884), a mansion adjacent to the Stowe House; and the Stowe Visitor Center (1873), with changing exhibitions.

The center offers exhibits, tours, reference library access, and occasional recreational and educational events.

The Sanchez Adobe was constructed between 1842 and 1846 by Francisco Sanchez, owner of Rancho San Pedro and one-time alcalde of San Francisco. Sanchez was a leader of Mexican California who led volunteers against United States forces at the Battle of Santa Clara. Today, the site shows the different periods of local history. Visitors can take a walk on the grounds and see native plants—the Ohlone village of Pruristac was located on the site. They can view the location of the original Spanish farm buildings; explore the Sanchez family's adobe home; and discover what items were uncovered during archaeological digs, including items from the adobe's time as a hotel and speakeasy.

The site offers exhibits and educational programs.

The Museum's historic building houses an object collection of over 1,600 items, including decorative arts, personal items, costumes, and memorabilia, related to James Monroe. Additionally, the on-site archives houses over 10,000 documents, and the library holds over 3,000 volumes of rare and historic books.

The museum offers exhibits, research library access, tours, and occasional recreational and educational events.

Stratford Hall, home of the Lee family and birthplace of Robert E. Lee, was built by Thomas Lee in the late 1730s. Today, it is furnished with an outstanding collection of predominantly 18th-century American and English decorative arts.

The site offers exhibits, tours, educational program, workshops, research library access, and occasional recreational and educational events (including living history events).

Winterthur, an American country estate, is the former home of Henry Francis du Pont (1880–1969), an avid antiques collector and horticulturist. In the early 20th century, H. F. du Pont and his father, Henry Algernon du Pont, designed Winterthur in the spirit of 18th- and 19th-century European country houses. Visitors to Winterthur will rediscover America's heritage through its collections of antiques and Americana and venture out over the fields and farmland to learn about the workings of a great American country estate. They can also wander through the 60-acre naturalistic Winterthur Garden, while children will wonder at the Winterthur's famous fairy-tale children's garden, Enchanted Woods, and enjoy hands-on learning in the Touch-It Room.

The site offers research library access, tours, exhibits, classes and workshops, educational programs, and recreational and educational events.