The Association for Preservation of Historic Natchitoches seeks to preserve areas of historic value in the oldest settlement in the Louisiana Purchase Territory. The Association maintains the Melrose Plantation and the Kate Chopin House. The Melrose story begins with Marie Therese Coincoin, a slave born in 1742; she was eventually she sold to a Frenchmen, Claude Thomas Pierre Metoyer. In time, Metoyer freed Marie Therese and 10 Franco-African children. Evidence points to Metoyer as the father of these children. Marie Therese and son Louis Metoyer received large grants of land including the present Melrose Plantation. This Creole-style home celebrates its most famous resident, Kate Chopin, and its original inhabitant, Alexis Cloutier. Built by slave labor between 1805 and 1809, the structure exemplifies the early 19th-century homes of the area.

The association offers occasional recreational and educational events; the plantation offers tours; the house offers exhibits and tours.

Belle Grove is an 18th-century grain and livestock farm, which, in its prime (circa 1815), encompassed about 7,500 acres of land. The unique limestone house was completed in 1797 for Major Isaac Hite and his wife Nelly, sister of future President James Madison. The house has remained virtually unchanged through the years, offering visitors an experience of the life and times of the people who lived there in the late 18th and early 19th centuries. During the Civil War, Belle Grove was at the center of the decisive Battle of Belle Grove or Cedar Creek. Today, the plantation includes the main house and gardens, original outbuildings, a classic 1918 barn, an overseer's house, the slave cemetery, a heritage apple orchard, fields and meadows, and scenic mountain views.

The site offers tours, educational programs, and occasional recreational and educational events (including living history events).

Mount Vernon was the beloved home of George and Martha Washington from the time of their marriage in 1759 until General Washington's death in 1799. He worked tirelessly to expand his plantation from 2,000 acres to 8,000 and the mansion house from six rooms to 21. Visitors are invited to tour the Mansion house and more than a dozen outbuildings including the slave quarters, kitchen, stables, and greenhouse. They can stroll four different gardens, hike the Forest Trail, and explore the "George Washington: Pioneer Farmer" site, a four-acre working farm that includes a recreation of Washington's 16-sided treading barn. George and Martha Washington rest in peace in the tomb where wreathlaying ceremonies are held daily, and the Slave Memorial and Burial Ground is nearby.

The site offers multimedia presentations, exhibits, tours, demonstrations, educational programs, river cruises, research library access, and recreational and educational events (including living history events).

This building was the capitol for only four days in 1855, but many believe that the actions of the legislature that met here led directly to the Civil War. Governor Andrew Reeder picked this location, away from the proslavery influence of Missouri, where the legislature would choose a permanent seat of government, create a constitution, and decide if Kansas would be a free or slave state. Instead the legislature kicked out the antislavery members and passed a bill to move the government to Shawnee Mission near the Missouri border. Inside this native stone building visitors will learn the stories of the antislavery and proslavery people of territorial Kansas, set alongside the beauty of the Kaw River Nature Trail.

The site offers exhibits, tours, and educational and recreational events.

The 1678 Joshua Hempsted House is one of New England's oldest and best documented dwellings. Joshua Hempsted lived here his whole life, filling many roles, including farmer, judge, gravestone carver, shipwright, and father of nine children left motherless by his wife's death in 1716. The Hempsted House survived the 1781 burning of New London by the British, commanded by traitor Benedict Arnold. Later, it may have been a safe house on the secret Underground Railroad which aided fugitive slaves seeking freedom. Adjacent to the Joshua Hempsted House is a rare stone dwelling built in 1759 by his grandson Nathaniel. Both houses' furnishings include original Hempsted family objects.

The houses offer exhibits and tours.

The Reginald F. Lewis Museum of Maryland African American History and Culture is dedicated to sharing the courageous journeys toward freedom and self-determination made by African-American Marylanders.

The museum offers tours, exhibits, educational programs, research library access, and recreational and educational events.

The Museum of African American History is dedicated to preserving, conserving, and accurately interpreting the contributions of African Americans in New England from the colonial period through the 19th century. The Museum maintains several individual historical sites, including the Boston African Meeting House, the Abiel Smith School, the Nantucket African Meeting House, and the Higginbotham House. The African Meeting House on Beacon Hill was built in 1806 in what once was the heart of Boston's 19th-century African-American community. It is today a showcase of black community organization in the formative years of the new republic. The 1834 Abiel Smith School is the first building in the nation built for the sole purpose of serving as a public school for black children. This historic site has been transformed into exhibit galleries. The African Meeting House on Nantucket is the island's most vivid reminder of a thriving 19th-century African-American community. Erected in the 1820s by the African Baptist Society (of which Captain Absalom Boston was a trustee), it is the only public building still in existence that was constructed and occupied by the island's African Americans during the 19th century.

The museum offers exhibits, tours, educational programs, lectures, and recreational and educational events; the Boston African Meeting House offers tours; the School offers exhibits; the Nantucket African Meeting House offers exhibits.

At the turn of the 20th century, the J. Thomas Newsome family moved to Newport News. In this industrial city, he established a law practice and prospered as part of the postwar South's new urban, black middle class. Through self-determination and a solid education, Newsome (1869–1942) became a respected attorney, journalist, churchman, and civic leader. His elegant Queen Anne residence served as the hub of the local black community from which he led the fight for social justice within the commonwealth. Today, this restored 1899 Victorian landmark continues to be devoted to the expression of black cultural and historical themes.

The center offers exhibits, educational programs, and occasional educational and recreational events (including living history events).

The Old Slave Mart, located on one of Charleston's few remaining cobblestone streets, is the only known extant building used as a slave auction gallery in South Carolina. Once part of a complex of buildings, the Slave Mart building is the only structure to remain. When it was first constructed in 1859, it has gone through numerous renovations and today serves as a museum, with a permanent exhibition divided into two main areas. In the orientation area, visitors receive an introduction to the domestic slave trade within the greater historical context of slavery in the United States as well an overview of the trans-Atlantic slave trade. In the main exhibit area visitors will also get a closer look at the daily process of slave sales at Ryan's Mart from the perspectives of a number of its historically documented buyers, traders, and enslaved African Americans. This section explains this antebellum slave market's role within Charleston's larger, but concentrated, slave-trading district.

The museum offers exhibits.

Darnall's Chance House Museum is dedicated to the interpretation and study of the history and culture of 18th-century Prince George's County, MD, with special emphasis on the lives of mid-18th-century women. The Museum interprets the story of the widow Lettice Wardrop Thomson Sim, who lived at Darnall's Chance in the decades just prior to the American Revolution. The house and grounds reflect 1760, the year Lettice Wardrop's first husband died and a room by room inventory was taken of the contents of the house. Darnall's Chance also strives to accurately reflect the African-American community on the site and town life in mid-18th-century Upper Marlboro, MD.

The site offers tours, educational programs, and occasional educational and recreational events.