The Felix Vallé State Historic Site is designed to offer visitors a rare glimpse of Missouri's French colonial past. From the historic site's website, "The site features the Felix Vallé House built in 1818 as an American-Federal style residence and mercantile store. Restored and furnished to reflect the 1830s, the home today interprets the American influence on the French community following the Louisiana Purchase." In addition to the Felix Vallé House, the historic site also features the Benjamin Shaw house and the 1792 Bauvais-Amoureux House.

The State Historic Site offers guided tours and interpretive activities, and serves as the headquarters for the Historic Preservation Field School. The website offers visitor information as well as a brief history of the site.

St. Joseph Lead Co. dominated ore production and became the heart of the easter Ozarks' Old Lead Belt, continuing operations in this district until 1972. In 1975, the company donated the 25 buildings of their largest mine-mill complex and the surrounding land to the Missouri Department of Natural Resources. These properties became Missouri Mines State Historic Site and St. Joe State Park. The 19,000 square-foot mine-mill powerhouse has been developed into a large museum that interprets Missouri's mining history and displays old mining machinery and an outstanding mineral collection.

The site offers a short film, exhibits, tours, and occasional recreational and educational events.

The 7.4–acre Battle of Carthage Historic Site preserves the location of the Battle of Carthage, one of the earliest engagements in the Civil War, fought 5 July, 1861. The site includes a portion of the battleground, as well as the site of both the Union and Confederate camps. The battle itself, a Confederate victory, was led by Union Colonel Franz Sigel and Confederate Governor Claiborne Jackson. In this skirmish, Sigel attempted to prevent Jackson's men from banding together with other nearby Confederate troops.

The site offers an informational kiosk.

Harry Truman was born in a modest frame house in Lamar, Missouri. The home has been faithfully preserved so that modern visitors can explore the home exactly as it was during the first year of Harry Truman's life. The home has no electricity or running water, and is furnished in a manner typical of the late 1800s.

The home offers guided tours. The website offers a brief history and visitor information.

In 1804, Lewis and Clark reported the presence of many saltwater springs in the area that now comprises Howard, Cooper, and Saline counties. The largest of these salt springs was the Boone's Lick. The area around this spring was ideal for settlement and for many years "Boone's Lick Country" was a primary destination for pioneers moving west. Nathan and Daniel Morgan Boone, sons of famous frontiersman Daniel Boone, formed a partnership with James and Jesse Morrison in 1805 to produce salt. Brine water was poured into iron kettles and heated to boiling on a stone furnace. As the water evaporated, salt crystallized in the bottom of the kettle. The salt was shipped by keelboat on the Missouri River to St. Louis. Salt, which was indispensable at the time for preserving meat and tanning hides, was produced at the site until approximately 1833. Today, the 52-acre site features picnic facilities and a short trail that winds its way to the spring site, where wood remnants of the salt works and an iron kettle are still visible. Outdoor exhibits interpret this unique saltwater environment and center of frontier industry. Artifacts from the salt manufacturing industry were excavated at the site, and some are on display at the Arrow Rock State Historic Site visitor center in Arrow Rock.

The site offers exhibits and occasional recreational and educational events.

The Pommer-Gentner house, built in 1840, is a sterling example of high-style German neoclassicism and is furnished to reflect the earlier settlement period of the 1830s and 1840s. Behind the house, visitors will tour a period garden and a small half-timbered barn containing an exhibit of 19th-century tools. The Strehly house, built in stages from 1842 to 1869, has a traditional German vernacular front. It once contained a full-service printing company that produced a German-language newspaper. About 1857, Carl Strehly built a winery next to the house that today displays one of a few remaining carved wine casks in the Midwest. Grapevines, planted by the Strehlys in the 1850s, can still be seen running the length of the backyard. Deutschheim's varied collections of German Americana are represented by galleries of changing artifacts and photographs.

The site offers tours, exhibits, occasional recreational and educational events.

Missouri's first legislators met in the buildings of the First Missouri State Capitol State Historic Site to undertake the task of reorganizing Missouri's territorial government into a progressive state system. From June 4, 1821, to Oct. 1, 1826, heated debates of state's rights and slavery filled the rooms of the temporary Capitol. The second floor of two adjoining Federal-style brick buildings was divided and used as Senate and House chambers, an office for the governor, and a small committee room. The first floor of the Peck brothers' building housed a general store and Ruluff Peck's family residence. Chauncy Shepard operated a carpenter shop on the first floor of the adjoining building. For a nominal fee, visitors can take a guided tour through the actual restored and furnished rooms where Missouri state government was created and first practiced. The restored Peck brothers' general store and residence have been furnished as they might have looked in the early 1800s. Admission is free to the historic site's interpretive center, which offers two floors of exhibits and an orientation show.

The site offers a short film, exhibits, tours, and occasional recreational and educational events.