The park's location is historically significant since it is in the heart of the former President's home country. The area has been influenced by three major cultures: Native Americans, Spanish, and German. Indians roamed the Hill Country first, leaving behind artifacts which tell of their nomadic life. The Spanish conquistadors followed, bringing a culture which was to endure to the present. German immigrants settled the Hill Country in the early 1800s and their descendants still call it home. Their culture has had a major impact on the development of the region and the park itself. All of these cultures are represented at the park. The Visitor Center contains memorabilia from President Johnson's presidency and interactive displays about the land and people that shaped a president. Attached to the Visitors Center is the Behrens Cabin, a two-room dogtrot cabin built by German immigrant H. C. Behrens during the 1870s. The furnishings are typical of such homes in that period. Visitors can further explore the history of these immigrants by viewing the 1860s Danz family log cabin located just west of the Visitor Center. Also located in the park is the Sauer-Beckmann Farm, a living history farm. Life on the farmstead is presented as it was in 1918. Park interpreters wear period clothing, do the farm and household chores as they were done at that time, and also conduct tours for the visitors.

The site offers exhibits, tours, demonstrations, and occasional recreational and educational events (including living history events).

The California Missions are among the United States's greatest cultural treasures. The 21 Spanish missions along the California coast have become some of the state's most significant cities, including San Francisco and San Diego. Founded in 1998, the California Missions Foundation was established with the objective of preserving and protecting the missions. The Foundation is the only organization dedicated to the long-term preservation and restoration needs of all California missions and their associated historic and cultural resources for public benefit.

The site offers a brief synopsis of all 21 missions supported by the foundation, a brief history of the missions in general, and information about past foundation successes and future preservation efforts.

The New Mexico History Museum presents the history of the state of New Mexico in six sections—five following the state from the days of Spanish colonization through stages up the present day, and the sixth focusing on modern New Mexicans' perceptions of their state.

The museum offers exhibits, research library access, and recreational and educational events.

The Texas Maritime Museum provides exhibits on the history and technology of offshore petroleum production and transportation; the history and development of Texas seaports, maritime communities, and maritime commerce along the Gulf; the exploration and settlement history of the Texas Gulf Coast, including by the Spanish and the French; and an overview of the Texas seafood and fishing industry.

The museum offers exhibits, tours for school groups, in-class outreach presentations, traveling trunk "treasure chests" for loan, and occasional recreational and educational events.

The Sanchez Adobe was constructed between 1842 and 1846 by Francisco Sanchez, owner of Rancho San Pedro and one-time alcalde of San Francisco. Sanchez was a leader of Mexican California who led volunteers against United States forces at the Battle of Santa Clara. Today, the site shows the different periods of local history. Visitors can take a walk on the grounds and see native plants—the Ohlone village of Pruristac was located on the site. They can view the location of the original Spanish farm buildings; explore the Sanchez family's adobe home; and discover what items were uncovered during archaeological digs, including items from the adobe's time as a hotel and speakeasy.

The site offers exhibits and educational programs.