The Harriet Beecher Stowe House is operated as an historical and cultural site, focusing on Harriet Beecher Stowe, author of Uncle Tom's Cabin. The site also includes a look into the family, friends, and colleagues of the Beecher-Stowe family; Lane Seminary; and the abolitionist, women's rights, and Underground Railroad movements in which these historical figures participated in the 1830s to 1860s, as well as African-American history related to these movements. The house was home to Harriet Beecher Stowe prior to her marriage and to her father, Rev. Lyman Beecher, and his large family, a prolific group of religious leaders, educators, writers, and antislavery and women's rights advocates. The Beecher family includes Harriet's sister, Catherine Beecher, an early female educator and writer who helped found numerous high schools and colleges for women; brother Rev. Henry Ward Beecher, a leader of the women's suffrage movement and considered by some to be the most eloquent minister of his time; General James Beecher, a Civil War general who commanded the first African-American troops in the Union Army recruited from the South; and sister Isabella Beecher Hooker, a women's rights advocate. The Beechers lived in Cincinnati for nearly 20 years, from 1832 to the early 1850s, before returning East.

The house offers exhibits, tours, and occasional recreational and educational programs and events.

The Rankin House was an important stop on the Underground Railroad in southern Ohio through which many slaves escaped from the South to freedom. John Rankin was a Presbyterian minister and educator who devoted much of his life to the antislavery movement. In 1826 he published his antislavery book, Letters on American Slavery. In 1834 he founded the Ohio Anti-Slavery Society in Zanesville. From 1825 to 1865, Rankin and his wife Jean, with their Brown County neighbors, sheltered more than 2,000 slaves escaping to freedom, with as many as 12 escapees being hidden in the Rankin home at one time. The house, a National Historic Landmark, is included in the National Underground Railroad to Freedom Network. Outside is a reconstruction of the stairway used by slaves to climb from the Ohio River to the Rankin House.

The house offers tours and educational programs.

The Moravian church founded Schoenbrunn ("beautiful spring") in 1772 as a mission to the Delaware Indians. The settlement grew to include sixty dwellings and more than 300 inhabitants who drew up Ohio's first civil code and built its first Christian church and schoolhouse. Problems associated with the American Revolution prompted Schoenbrunn's closing in 1777. Schoenbrunn's story features a rare meeting of Indian and European cultures and a fascinating perspective on the American Revolution. Today the reconstructed village includes 17 log buildings, gardens, the original mission cemetery, and a museum and visitor center.

The village offers a short film, exhibits, and tours.

On a high sand terrace above the Des Moines River floodplain in northeast Missouri sets Iliniwek Village State Historic Site, the largest and best preserved remnant known of any Illinois Indian village. This site was occupied from ca. A.D. 1640-1683, when Europeans were just contacting Native Americans in this region. During excavations in the 1990s, the locations of numerous houses, storage pits and even a ditch and palisade fortification were discovered. The Illinois Indians were the first Native Americans that Louis Jolliet and Father Jacques Marquette encountered in present-day Missouri in 1673. At that time, the village contained 300 lodges and perhaps 8,000 people. Evidence of early European contact appears in archaeological finds through glass beads, metal objects, and Jesuit trade rings. The historic site interprets the history and daily life of the Illinois Indians and the Jolliet and Marquette expedition of 1673. A short walking trail crosses the site, and the location of an excavated Illinois Indian longhouse is marked to show its size.

The site offers exhibits, tours, and occasional recreational and educational events.

This three-story brick building was erected in Mount Pleasant in 1814 and was the first yearly Quaker meeting house west of the Alleghenies. Capable of holding 2,000 persons, the building contains an auditorium with a balcony. The auditorium can be divided into two rooms by lowering a wooden partition; when the building was actively used by Quakers, men and women met separately. Jesse Thomas and Robert Carothers laid out Mount Pleasant in 1803. It soon became an important market for Quaker settlers. The Mount Pleasant meeting house was used regularly until 1909.

The house offers tours.