This is one of the richest collections of anti-slavery and Civil War materials in the world. Reverend Samuel J. May, an American abolitionist, donated his collection of anti-slavery materials to the Cornell Library in 1870. Following May's lead, other abolitionists in the U.S. and Great Britain contributed materials. The collection now consists of more than 10,000 pamphlets, leaflets, broadsides, local anti-slavery society newsletters, sermons, essays, and arguments for and against slavery. Materials date from 1704 to 1942 and cover slavery in the United States and the West Indies, the slave trade, and emancipation. More than 300,000 pages are available for full-text searching. Accompanying the documents are eight links to other collections.

An ambitious attempt to digitize 19th-century American fiction as listed in Lyle Wright's bibliography, American Fiction, 1815–1875, this collection of texts is a work-in-progress. At present, the website offers close to 3,000 texts by 1,456 authors. These include the well known, such as Louisa May Alcott and Mark Twain as well as hundreds of less well-known authors. Topics include slavery, reform, education, politics, love, children, and war. Close to 800 have been fully edited and SGML-encoded so that users may access chapter and story divisions through table of content hyperlinks. The remaining texts can be read either as facsimiles of original pages or in unedited transcriptions. The ability to perform single word and phrase searches on all material in the database—whether fully encoded or not—is powerful.

Thirty-five of the most important documents in the early history of the United States are presented here, accompanied by ample contextualization from the Library of Congress's vast collections. In addition to the "founding documents," the collection includes George Washington's Commission as Commander in Chief (1775), the Federalist Papers (1787–1788), the Alien and Sedition Acts (1798), the Louisiana Purchase (1803), the Missouri Compromise (1820), the Indian Removal Act (1830), Dred Scott v. Sandford (1857) case, the Emancipation Proclamation (1863), and the Thirteenth, Fourteenth, and Fifteenth Amendments to the Constitution. Each document is annotated and accompanied by a related primary source image. Links to American Memory collections and Library of Congress Exhibitions containing additional contextual documents and other secondary source interpretations are also provided, as are links to external websites and a selected bibliography.

Thomas Jefferson outlined three motivating factors in his instructions to Lewis and Clark: a search for navigable rivers to span the continent; a quest for Edenic beauty and riches; and the competitive desire to acquire a continental empire. These 180 documents and artifacts interpret 19th-century westward exploration from this perspective. The range of materials is striking. In addition to maps, plans, and charts, the site offers images (sketches, watercolors, etchings, and engravings), texts (letters, diaries, speeches, newspapers, and books), and tools (surveying and medical instruments, cooking utensils, armaments). The exhibit opens with an examination of the "imperial mentality" common to Virginia's aristocratic class in the late 18th century and then focuses on the Lewis and Clark journey. It ends with the subsequent expeditions of Zebulon Pike, Stephen H. Long, Charles Wilkes, John Charles Fremont, and the mid-19th century transcontinental railroad plan that supplanted the search for a water route.

More than 100 published materials on legal aspects of slavery are available on this website. These include 8,700 pages of court decisions and arguments, reports, proceedings, journals, and a letter. Most of the pamphlets and books pertain to American cases in the 19th century. Additional documents address the slave trade, slave codes, the Fugitive Slave Law, and slave insurrections as well as presenting courtroom proceedings from famous trials such as the 18th-century Somerset v. Stewart case in England, the Amistad case, the Denmark Vesey conspiracy trial, and trials of noted abolitionists John Brown and William Lloyd Garrison. A special presentation discusses the slave code in the District of Columbia. Searchable by keyword, subject, author, and title, this site is valuable for studying legal history, African American history, and 19th-century American history.

The Dred Scott case began in 1846 when slaves Dred and Harriet Scott sued for their freedom, basing their argument on the fact that they had lived in non-slave territories for a number of years. The case ended with the landmark U.S. Supreme Court decision of 1857 that not only denied Scott both citizenship and the right to sue in federal court, but ruled that he never had been free and that Congress did not have the right to prohibit slavery in the territories. The decision sparked increased sectional tensions in the years leading to the Civil War. Facsimiles and transcriptions of 85 legal documents relating to the Dred Scott case are provided on this website. The site also provides a chronology and links to 301 Freedom Suits—legal petitions for freedom filed by or on behalf of slaves—in St. Louis courts from 1814 to 1860.